Clinical Studies and Product Compounds
Charged with the development of an
ANABOLIC
AGENT capable of mimicking the incredible potency and laser precision
defining results of the legendary cutting steroid Winstrol, our premiere
scientists have done it again! Steroids.com’s WIN-ALT is a remarkable
scientifically engineered formula that’s designed to cut you to
ribbons. Its uniquely complex proprietary blend of ingredients
represents the very latest in technological synergy and advanced
muscular
definition.
At Steroids.com, we realize product
integrity
is no longer a given, but we’re confident in the quality of our ANABOLIC
AGENTS and have always contended that an informed consumer is our best
customer. The following material represents our challenge to you.
Below you’ll find this product’s primary ingredients, their respective
properties, how they work to build you a better body, and authentic
EXCERPTS from prestigious medical journals which include the study
aims/purposes
and conclusions. To view the entire clinical abstract, please
click the provided hyperlink beneath each excerpt. Thank you for
investigating Steroids.com and for the opportunity to prove our value!
WIN-ALT INGREDIENTS
Vanadyl Sulfate
(Vanadium)
Vanadyl Sulfate is the most popular and
common form of vanadium, an element in the body that is found in foods
such as pepper, dill, radishes, eggs, vegetable oils, buckwheat, and
oats.
To properly comprehend the importance
of Vandayl Sulfate, you must first understand the role and the rationale
behind wanting to artificially increase insulin. Sugar metabolism
is the process by which the body converts food into energy that can
be used by muscle cells. This process begins when enzymes break
food down into glucose, a simple six carbon sugar that can be easily
absorbed in the intestines where it is crucial in the delivery of energy
to cells for survival and functioning. In the body, glucose is
the standard form of energy after digestion. Unfortunately, glucose's
size and structure make it hard for the molecule to pass through the
outer membranes of many of the body's cells. Insulin bonds with the
outer membrane of cells to increase their permeability. This enables
glucose to pass through the cell membrane more easily and gives the
cell access to more energy. Without insulin, it is extremely difficult
for glucose in the blood to be used by the body's cells as energy.
Conversely,
an abundance of insulin increases the rate at which it is used by the
cells and subsequently lowers the amount of glucose left in the
bloodstream.
In addition to helping to provide cells
with energy, insulin also helps cells in other ways. When insulin
increases
the permeability of the cell membrane, amino acids also enter the cell.
These amino acids are used to build and repair cell parts and are
specifically
helpful in enhancing muscle cell growth.
General Uses:
The physiological role of vanadyl in
humans is that of a cofactor, in that it possesses insulin-mimicking
activities which support the body when actual insulin is in short supply
or unavailable. This trace element is very important for normal
growth and development. Specifically, it works by altering the
concentration and effectiveness of several enzymes that are involved
in the breakdown and distribution of glucose molecules and amino acids.
Anabolic Benefits:
To the body builder, such a substance
would be crucial, as more insulin in the body would provide more energy
for workouts, more rapid muscle repair, and greater strength gains.
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“To investigate the efficacy and
mechanism
of action of vanadium salts as oral hypoglycemic agents, 16 type 2
diabetic
patients were studied before and after 6 weeks of vanadyl sulfate
(VOSO4)
treatment at three doses…Vanadyl sulfate appears safe at these doses
for 6 weeks, but at the tolerated doses, it does not dramatically
improve
insulin sensitivity or glycemic control. Vanadyl modifies proteins in
human skeletal muscle involved in early insulin signaling, including
basal insulin receptor and substrate tyrosine phosphorylation and
activation
of PI 3-kinase, and is not additive or synergistic with insulin at these
steps...”
Metabolic effects of vanadyl sulfate
in humans with non-insulin-dependent diabetes mellitus: in vivo and
in vitro studies.”
Goldfine AB, Patti
ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn CR.
Metabolism. 2000 Mar;49(3):400-10.
http://www.ncbi.nlm.nih.gov/pubmed/10726921
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“BACKGROUND/AIM: Impaired glucose
tolerance
(IGT) is considered a risk factor for developing type 2 diabetes
mellitus
(T2DM) and is associated with insulin resistance. Vanadium seems to
block protein tyrosine phosphatase with the consequent increment in
insulin sensitivity (INS) in T2DM patients, but this effect has not
been studied in IGT patients. The aim of this study was to evaluate
the effect of vanadium on INS in IGT patients…CONCLUSIONS: VS
administration
in IGT patients increased triglyceride concentrations without changes
in INS.”
Effect of vanadium on insulin
sensitivity
in patients with impaired glucose tolerance.
Jacques-Camarena O, González-Ortiz M, Martínez-Abundis E, López-Madrueño JF, Medina-Santillán R.
Ann Nutr Metab. 2008;53(3-4):195-8. Epub 2008 Nov 22.
http://www.ncbi.nlm.nih.gov/pubmed/19033682
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“BACKGROUND: Vanadyl sulfate (VS) and
taurine are two promising agents in the treatment of diabetes related
to their antihyperglycemic, antihyperlipidemic, and hyperinsulinemic
effects…CONCLUSIONS: The findings of the present study suggest that
VS and taurine exert beneficial effects on the blood glucose and lipid
levels in STZ-NA diabetic rats. However, VS might exert prooxidative
or antioxidative effects in various components of the body and taurine
and VS combination might be an alternative for sole VS administration.”
Vanadyl sulfate, taurine, and combined
vanadyl sulfate and taurine treatments in diabetic rats: effects on
the oxidative and antioxidative systems.
Tas S, Sarandol E, Ayvalik SZ, Serdar Z, Dirican M.
Arch Med Res. 2007 Apr;38(3):276-83. Epub 2007 Jan 22.
http://www.ncbi.nlm.nih.gov/pubmed/17350476
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“High fructose feeding induces insulin
resistance, impaired glucose tolerance, and hypertension in rats and
mimics most of the features of the metabolic syndrome X. The effects
of a 6-week treatment with the transition metals administered in
drinking
water, vanadium (VOSO4.5H2O, 0.75 mg/mL) or tungsten (Na2O4W, 2 g/mL),
were investigated on the reactivity to norepinephrine (NEPI) or
acetylcholine
(ACh) of thoracic aorta rings isolated from fructose (60%) or standard
chow fed rats…Vanadium, but not tungsten, increased the relaxing
activity
of ACh, both in control and fructose-fed animals. Insulin resistance
associated with high fructose feeding was reversed by vanadium but not
by tungsten treatment. The differential effects of the two transition
metals on vascular responsiveness to NEPI or ACh may be explained by
their differential effects on insulin sensitivity.”
Differential effects of sodium
tungstate
and vanadyl sulfate on vascular responsiveness to vasoactive agents
and insulin sensitivity in fructose-fed rats.
Al-Awwadi N, Bichon-Laurent
F, Dimo
T, Michel
A, Portet
K, Cros
G, Poucheret
P.
Can J Physiol Pharmacol. 2004 Oct;82(10):911-8.
http://www.ncbi.nlm.nih.gov/pubmed/15573152
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“Nitric oxide (NO) has been shown to
act as a mediator of cytokines in bone tissue. We have previously
demonstrated
that vanadium compounds are insulin- and growth factor-mimetic compounds
in osteoblasts in culture, although high doses are toxic to these
cells…Experiments
performed with the ionophore A23187 and EGTA suggested that
vanadate-induced
NO production involves Ca(2+)-dependent and -independent mechanisms.
Altogether, our results suggest that NO may play a critical role in
the bioactivity of vanadium in osteoblast-like cells.”
Vanadate-induced nitric oxide
production:
role in osteoblast growth and differentiation.
Cortizo AM, Caporossi
M, Lettieri
G, Etcheverry
SB.
Eur J Pharmacol. 2000 Jul 21;400(2-3):279-85.
http://www.ncbi.nlm.nih.gov/pubmed/10988345
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“Occupational exposure by inhalation
to vanadium-containing particles such as residual oil fly ash results
in respiratory tract inflammation. This inflammation, characterized
by abundant neutrophilia, appears to be initiated by alveolar
macrophages
(AMs) encountering particles and the subsequent release of
proinflammatory
cytokines…These observations demonstrate that in vitro metavanadate
exposure regulates two distinct, yet related intracellular signaling
pathways important in initiating inflammatory responses in these cells:
(1) activation of the NADPH oxidase complex with subsequent increased
ROI synthesis, and (2) enhanced tyrosine phosphorylation of cellular
proteins.”
Mediating phosphorylation events in
the vanadium-induced respiratory burst of alveolar macrophages.
Grabowski GM, Paulauskis
JD, Godleski
JJ.
Toxicol Appl Pharmacol. 1999 May 1;156(3):170-8.
http://www.ncbi.nlm.nih.gov/pubmed/10222309
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“Diabetes mellitus is accompanied by
hormonal and neurochemical changes that can be associated with anxiety
and depression. Both diabetes and depression negatively interact, in
that depression leads to poor metabolic control and hyperglycemia
exacerbates
depression. We hypothesize one novel vanadium complex of
vanadium-enriched
Cordyceps sinensis (VECS), which is beneficial in preventing depression
in diabetes, and influences the long-term course of glycemic control.
Vanadium compounds have the ability to imitate the action of insulin,
and this mimicry may have further favorable effects on the level of
treatment satisfaction and mood. C. sinensis has an antidepressant-like
activity, and attenuates the diabetes-induced increase in blood glucose
concentrations. We suggest that the VECS may be a potential strategy
for contemporary treatment of depression and diabetes through the
co-effect
of C. sinensis and vanadium. The validity of the hypothesis can most
simply be tested by examining blood glucose levels, and swimming and
climbing behavior in streptozotocin-induced hyperglycemic rats.”
A Contemporary Treatment Approach
to Both Diabetes and Depression by Cordyceps sinensis, Rich in Vanadium.
Guo JY, Han CC, Liu YM.
Evid Based Complement Alternat
Med. 2009 Nov 30.
http://www.ncbi.nlm.nih.gov/pubmed/19948751
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Dandelion
GENERAL USES:
Dandelion, also know as Taraxacum
Officinale,
has been a staple of the traditional herbal pharmacopeia for centuries.
In Europe, the dandelion is highly respected as the nutritional and
medicinal powerhouse.
Among other things, dandelion root and
other plants of the dandelion have been used as a mild laxative and
potent diuretic combination, a digestive aid, a treatment for liver
and kidney problems, inflammation relief, boils, fever and diarrhea.
Dandelion root is known to stimulate the appetite and as a substantial
anti-oxidant. In Europe dandelion greens are often added to salads and
used in the same way as lettuce and other greens, and is believed to
help regulate blood sugar levels.
ANABOLIC BENEFITS:
“Flavonoids and coumaric acid derivatives
were identified from dandelion flower (Taraxacum officinale).
Characteristics
of chain-breaking antioxidants, such as extended lag phase and reduced
propagation rate, were observed in oxidation of linoleic acid emulsion
with the addition of dandelion flower extract (DFE). DFE suppressed
both superoxide and hydroxyl radical, while the latter was further
distinguished
by both site-specific and non-specific hydroxyl radical inhibition…These
results showed that the DFE possessed marked antioxidant activity in
both biological and chemical models. Furthermore, the efficacy of DFE
in inhibiting both reactive oxygen species and nitric oxide were
attributed
to its phenolic content.”
Dandelion (Taraxacum officinale)
flower
extract suppresses both reactive oxygen species and nitric oxide and
prevents lipid oxidation in vitro.
Hu C, Kitts DD.
Phytomedicine. 2005 Aug;12(8):588-97.
http://www.ncbi.nlm.nih.gov/pubmed/16121519
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“Latex of dandelion roots contains
a serine proteinase that hydrolyzes a chromogenic peptide substrate
Glp-Ala-Ala-Leu-pNA optimally at pH 8.0…Pure serine proteinase named
taraxalisin was inactivated by specific inhibitors of serine
proteinases,
diisopropylfluorophosphate (DFP) and phenylmethylsulfonylfluoride
(PMSF).
The substrate specificity of taraxalisin towards synthetic peptides
and insulin B-chain is comparable with that of two other subtilisin-like
serine proteinases, cucumisin and macluralisin. The taraxalisin
N-terminal
sequence traced for 15 residues revealed 40% coinciding residues when
aligned with that of subtilisin Carlsberg.”
Taraxalisin -- a serine proteinase
from dandelion Taraxacum officinale Webb s.l.
Rudenskaya GN, Bogacheva
AM, Preusser
A, Kuznetsova
AV, Dunaevsky
YaE, Golovkin
BN, Stepanov
VM.
FEBS Lett. 1998 Oct 23;437(3):237-40.
http://www.ncbi.nlm.nih.gov/pubmed/9824298
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“Nitric oxide (NO) produced at high
concentrations by the inducible NO synthase is an important effector
molecule involved in immune regulation and defense. The involvement
of NO in the toxicity of cadmium (Cd) has been proposed. In the present
study, we searched restoration drug against the inhibition of NO
production
by Cd in Oriental medicine. An aqueous extract of Taraxacum officinale
(Compositae) (TOAE) restored the inhibition of NO production by mouse
peritoneal macrophages pretreated with Cd in a dose-dependent manner.
The effect of TOAE was mainly dependent on TOAE-induced tumor necrosis
factor-alpha (TNF-alpha) secretion. These results suggest that the
capacity
of TOAE to restore NO production from interferon-gamma
(IFN-gamma)-primed
mouse peritoneal macrophages is the result of TOAE-induced TNF-alpha
secretion.”
Taraxacum officinale restores
inhibition
of nitric oxide production by cadmium in mouse peritoneal macrophages.
Kim HM, Lee EH, Shin TY, Lee KN, Lee JS.
Immunopharmacol Immunotoxicol. 1998 May;20(2):283-97.
http://www.ncbi.nlm.nih.gov/pubmed/9653673
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“To investigate the efficacy and the
mechanism of the anti-inflammatory effect of Taraxacum officinale leaves
(TOLs), the effect of a methanol extract and its fractions recovered
from TOLs on lipopolysaccharide (LPS)-induced responses was studied
in the mouse macrophage cell line, RAW 264.7…These results show that
the anti-inflammatory effects of TOLs are probably due to
down-regulation
of NO, PGE(2), and pro-inflammatory cytokines and reduced expressions
of iNOS and COX-2 via inactivation of the MAP kinase signal pathway.”
Anti-Inflammatory Effect of Taraxacum
officinale Leaves on Lipopolysaccharide-Induced Inflammatory Responses
in RAW 264.7 Cells.
Koh YJ, Cha DS, Ko JS, Park HJ, Choi HD.
J Med Food. 2010 Aug;13(4):870-8.
http://www.ncbi.nlm.nih.gov/pubmed/20673058
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Caffeine
Caffeine is a central nervous system
stimulant most often found in coffee beans and tea leaves. Clinical
studies have shown its effects to extremely diverse and apparently
contingent
upon the uses for which it is employed making it an excellent
facilitator/ancillary
ingredient that literally amplifies the properties of other products.
General Uses:
Caffeine is primarily used to stimulate
metabolic rate and, in so doing, promote alertness, reduce drowsiness
and improve coordination. It has been found to increase energy
expenditure and thereby enhance weight loss and fat loss activities.
Recent clinical data has demonstrated that caffeine in conjunction with
routine anabolic training can actually increase strength levels in the
user (see below).
Anabolic Benefits:
“…Therefore, the purpose of this
study was to determine the acute effects of caffeine supplementation
on strength and muscular endurance in resistance-trained women…RESULTS:
Repeated measures ANOVA indicated a significantly greater bench press
maximum with caffeine (p </= 0.05) (52.9 +/- 11.1 kg vs. 52.1 +/-
11.7 kg) with no significant differences between conditions in 60% 1RM
repetitions (p = 0.81). Systolic blood pressure was significantly
greater
post-exercise, with caffeine (p < 0.05) (116.8 +/- 5.3 mmHg vs. 112.9
+/- 4.9 mmHg). CONCLUSIONS: These findings indicate a moderate dose
of caffeine may be sufficient for enhancing strength performance in
resistance-trained women.”
Caffeine enhances upper body strength
in resistance-trained women.
Goldstein E, Jacobs
PL, Whitehurst
M, Penhollow
T, Antonio
J.
J Int Soc Sports Nutr. 2010 May 14;7:18.
http://www.ncbi.nlm.nih.gov/pubmed/20470411
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“A series of four trials was carried
out to investigate the effects of caffeine and coffee on the metabolic
rate and substrate utilization in normal weight and obese
individuals…In conclusion
caffeine/coffee stimulates the metabolic rate in both control and obese
individuals; however, this is accompanied by greater oxidation of fat
in normal weight subjects.”
Caffeine and coffee: their influence
on metabolic rate and substrate utilization in normal weight and obese
individuals.
KJ Acheson, B Zahorska-Markiewicz, P
Pittet, K Anantharaman and E Jequier (1980)
American Journal of Clinical Nutrition,
Vol 33, 989-997
http://www.ajcn.org/cgi/content/abstract/33/5/989?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=caffeine+fat+loss&searchid=1&FIRSTINDEX=10&resourcetype=HWCIT
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“Single-dose oral administration of
100 mg caffeine increased the resting metabolic rate of both lean and
postobese human volunteers by 3-4%…The net effect was a significant
increase (p less than 0.02) in daily energy expenditure of 150 kcal in
the lean volunteers and 79 kcal in the postobese subjects. Caffeine
at commonly consumed doses can have a significant influence on energy
balance and may promote thermogenesis the treatment of obesity.”
Normal caffeine consumption: influence
on thermogenesis and daily energy expenditure in lean and post-obese
human volunteers.
Dulloo, A. G., Geissler, C. A., Horton,
T., Collins, A. and Miller, D. S. (1989)
American Journal of Clinical Nutrition.
49, 44-50.
http://www.ajcn.org/cgi/content/abstract/49/1/44?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=Normal+caffeine+consumption:+influence+on+thermogenesis+and+daily+energy+expenditure+in+lean+and+post-obese+human+volunteers.&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
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