Clinical Studies and Product Compounds
By synergistically recruiting the
properties
of both THERMOGENIC and LIPOLYTIC agents, Steroids.com’s scientifically
designed formula represents the most effective alternative available
to the ever popular prescription strength, fat-burning chemical
Clenbuterol.
CLEN-ALT possesses the unique ability to simultaneously target muscle
blurring subcutaneous fat (beneath the skin), and adipose fat (deposits
between organs) with unparalleled precision and results.
At Steroids.com, we realize product
integrity
is no longer a given, but we’re confident in the quality of our ANABOLIC
AGENTS and have always contended that an informed consumer is our best
customer. The following material represents our challenge to you.
Below you’ll find this product’s primary ingredients, their respective
properties, how they work to build you a better body, and authentic
EXCERPTS from prestigious medical journals which include the study
aims/purposes
and conclusions. To view the entire clinical abstract, please
click the provided hyperlink beneath each excerpt. Thank you for
investigating Steroids.com and for the opportunity to prove our value!
CLEN-ALT
INGREDIENTS:
L-Arginine
L-arginine is an amino acid that
initiates
and participates in numerous bio-organic functions throughout the body
such as regulating pH levels, supporting endothelial cells, assisting
in the ridding of ammonia and other waste products, the building of
necessary compounds like creatine, L-glutamate, and L-proline, and can
be converted to glucose and glycogen if needed.
General Uses:
In larger amounts, L-arginine stimulates
the release of growth hormone and prolactin and is also used to make
the nitric oxide, a compound in the body that relaxes blood vessels.
Preliminary studies have found that L-arginine may help with conditions
that improve when blood vessels are relaxed (called vasodilation), such
as atherosclerosis, erectile dysfunction, and intermittent
claudication.
L-arginine is thought to enhance the action of nitric oxide, which
relaxes
muscles surrounding blood vessels supplying the penis. As a result,
blood vessels in the penis dilate, increasing blood flow which helps
maintain an erection. One 50 subject study of men with erectile
dysfunction compared a 5 grams a day dosage of L-arginine to that of
a placebo, and six weeks later the L-arginine group showed marked
improvement.
With regard to its contribution to
physical
exercise, L-arginine possesses a multi-faceted effect spearheaded by
a unique anti-fatiguing property which can increase training duration
and shorten recovery time, but, even more importantly, L-arginine can
increase in overall strength.
Anabolic Benefits:
“A decrease of the blood supply to
the muscle can be significant to the development of muscular fatigue,
an important factor of incapacity. In this study, the effect of
L-arginine
taken orally, on the physiologic process of the muscular fatigue in
12 healthy volunteers, was investigated through located exercise
controlled
by isokinetic dynamometer (Biodex Multi-Joint System 3
dynamometer)…There
was a significant decrease (mean 8.5%) indicating an improvement in
the muscular resistance capacity to fatigue following the treatment
by oral administration of arginine.”
Study of the effect of oral
administration
of L-arginine on muscular performance in healthy volunteers: An
isokinetic
study
R.S. Santos, M.T.T. Pacheco, R.A.B.L.
Martins, A.B. Villaverde, H.E. Giana4, F. Baptista, R.A.
Zângaro (2002)
Isokinetics and Exercise
Science Vol. 10,153-158
http://iospress.metapress.com/content/cau9ar6nck6fwpm9/
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“OBJECTIVE: We evaluated the
pharmacokinetics, safety, and efficacy of l-arginine alpha-ketoglutarate
(AAKG) in trained adult men…CONCLUSION: AAKG supplementation appeared
to be safe and well tolerated, and positively influenced 1RM bench press
and Wingate peak power performance. AAKG did not influence body
composition
or aerobic capacity.”
Pharmacokinetics, safety, and effects
on exercise performance of L-arginine alpha-ketoglutarate in trained
adult men.
Campbell B, Roberts
M, Kerksick
C, Wilborn
C, Marcello
B, Taylor
L, Nassar
E, Leutholtz
B, Bowden
R, Rasmussen
C, Greenwood
M, Kreider
R. (2006)
Nutrition.(9):872-81.
http://www.ncbi.nlm.nih.gov/pubmed/16928472
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“The purpose of this study was to
investigate
the effects of an L-arginine and antioxidant supplement on exercise
performance in elderly male cyclists…The anaerobic threshold for the
supplement groups was significantly higher than that of placebo group
at week 1 and week 3…This study indicated a potential role of L-arginine
and antioxidant supplementation in improving exercise performance in
elderly.”
Arginine and antioxidant supplement
on performance in elderly male cyclists: a randomized controlled trial
Chen Steve, Woosong Kim, Henning Susanne,
Carpenter Catherine, Li Zhaoping (2010)
Journal of the International Society
of Sports Nutrition. 7:13doi:10.1186/1550-2783-7-13
http://www.jissn.com/content/7/1/13
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Yohimbine
The bark extract of the Pausinystalia
yohimbe tree that has been clinically proven to contain numerous
medicinal
properties, as well as support lipolysis.
General Uses:
The ability to increase saliva in people
experiencing Dry Mouth caused by medications, such as antidepressants,
and has been shown in multiple human trials to effectively treat
Erectile
Dysfunction (male impotence); demonstrated in pre-clinical studies to
inhibit platelet aggregation; used to increase libido in both men and
women; and shown to reduce high blood pressure.
Fat-Burning Benefits:
“Administered prior to exercise,
it boosts lipolysis and serum FFA levels both during and following
exercise…These
considerations suggest that pre-exercise administration of yohimbine
will lower the respiratory quotient during and following exercise, thus
promoting fat loss…A possible synergism of yohimbine and caffeine
should be explored.”
Pre-exercise administration of
yohimbine
may enhance the efficacy of exercise training as a fat loss strategy
by boosting lipolysis.
McCarty MF.
Med Hypotheses. 2002 Jun;58(6):491-5.
http://www.ncbi.nlm.nih.gov/pubmed/12323115
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“Percentage of body fat significantly
decreased in the yohimbine group after the supplementation protocol…”
Yohimbine: the effects
on body composition and exercise performance in soccer players.
Ostojic SM.
Res Sports Med. 2006
Oct-Dec;14(4):289-99.
http://www.ncbi.nlm.nih.gov/pubmed/17214405
--------------------
“Oral yohimbine administration (0.2
mg/kg) induced lipid [fat] mobilization (increase in plasma
non-esterified
fatty acids, NEFA) in fasting non-obese women…”
Plasma catecholamine levels
and lipid mobilization induced by yohimbine in obese and non-obese
women.
Berlan M, Galitzky J, Riviere D, Foureau
M, Tran MA, Flores R, Louvet JP, Houin G, Lafontan M.
Int J Obes. 1991 May;15(5):305-15.
http://www.ncbi.nlm.nih.gov/pubmed/1885256
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Caffeine
Caffeine is a central nervous system
stimulant most often found in coffee beans and tea leaves. Clinical
studies have shown its effects to extremely diverse and apparently
contingent
upon the uses for which it is employed making it an excellent
facilitator/ancillary
ingredient that literally amplifies the properties of other products.
General Uses:
Caffeine is primarily used to stimulate
metabolic rate and, in so doing, promote alertness, reduce drowsiness
and improve coordination. It has been found to increase energy
expenditure and thereby enhance weight loss and fat loss activities.
Recent clinical data has demonstrated that caffeine, in conjunction
with routine anabolic training, can actually increase strength levels
in the user (see below).
Anabolic Benefits:
“…Therefore, the purpose of this
study was to determine the acute effects of caffeine supplementation
on strength and muscular endurance in resistance-trained women…RESULTS:
Repeated measures ANOVA indicated a significantly greater bench press
maximum with caffeine (p </= 0.05) (52.9 +/- 11.1 kg vs. 52.1 +/-
11.7 kg) with no significant differences between conditions in 60% 1RM
repetitions (p = 0.81). Systolic blood pressure was significantly
greater
post-exercise, with caffeine (p < 0.05) (116.8 +/- 5.3 mmHg vs. 112.9
+/- 4.9 mmHg). CONCLUSIONS: These findings indicate a moderate dose
of caffeine may be sufficient for enhancing strength performance in
resistance-trained women.”
Caffeine enhances upper body strength
in resistance-trained women.
Goldstein E, Jacobs
PL, Whitehurst
M, Penhollow
T, Antonio
J.
J Int Soc Sports Nutr. 2010 May 14;7:18.
http://www.ncbi.nlm.nih.gov/pubmed/20470411
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“A series of four trials was carried
out to investigate the effects of caffeine and coffee on the metabolic
rate and substrate utilization in normal weight and obese
individuals…In conclusion
caffeine/coffee stimulates the metabolic rate in both control and obese
individuals; however, this is accompanied by greater oxidation of fat
in normal weight subjects.”
Caffeine and coffee: their influence
on metabolic rate and substrate utilization in normal weight and obese
individuals.
KJ Acheson, B Zahorska-Markiewicz, P
Pittet, K Anantharaman and E Jequier (1980)
American Journal of Clinical Nutrition,
Vol 33, 989-997
http://www.ajcn.org/cgi/content/abstract/33/5/989?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=caffeine+fat+loss&searchid=1&FIRSTINDEX=10&resourcetype=HWCIT
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“Single-dose oral administration of
100 mg caffeine increased the resting metabolic rate of both lean and
postobese human volunteers by 3-4%…The net effect was a significant
increase (p less than 0.02) in daily energy expenditure of 150 kcal in
the lean volunteers and 79 kcal in the postobese subjects. Caffeine
at commonly consumed doses can have a significant influence on energy
balance and may promote thermogenesis the treatment of obesity.”
Normal caffeine consumption: influence
on thermogenesis and daily energy expenditure in lean and post-obese
human volunteers.
Dulloo, A. G., Geissler, C. A., Horton,
T., Collins, A. and Miller, D. S. (1989)
American Journal of Clinical Nutrition.
49, 44-50.
http://www.ajcn.org/cgi/content/abstract/49/1/44?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=Normal+caffeine+consumption:+influence+on+thermogenesis+and+daily+energy+expenditure+in+lean+and+post-obese+human+volunteers.&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
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Capsaicin
General Uses:
Capsaicin is the heating ingredient found
in different types of hot peppers that makes them spicy hot. It
can be consumed in raw or cooked peppers or as a dried powder often
added to food or drinks.
Capsaicin is also available as a dietary
supplement and in topical creams that you apply to your skin.
The supplement is used to temporarily increase the metabolic rate by
heating the body from within and triggering a homeostatic cool down,
which burns calories. Capsaicin cream or ointment is used on the
skin (topical use) as a pain reliever. It works by first stimulating
and then decreasing the intensity of pain signals in the body.
Anabolic Benefits:
“The aim of the present study
was to investigate whether capsaicin assists weight maintenance by
limiting
weight regain after weight loss of 5 to 10 %...Fat oxidation (g/h) after
weight maintenance was higher in the capsaicin group compared with
placebo
(4.2 (SD 1.1) v. 3.5 (SD 0.9), P<0.05). These results indicate that
capsaicin treatment caused sustained fat oxidation during weight
maintenance
compared with placebo...”
Effect of capsaicin on substrate
oxidation
and weight maintenance after modest body-weight loss in human subjects.
Lejeune MP, Kovacs
EM, Westerterp-Plantenga
MS. (2003)
Br J Nutr.90(3):651-59.
http://www.ncbi.nlm.nih.gov/pubmed/13129472
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“In muscle cells the sarcoplasmic
reticulum
(SR) Ca2+-ATPase (SERCA) couples the free energy of ATP
hydrolysis
to pump Ca2+ ions from the cytoplasm to the SR lumen. In
addition,
SERCA plays a key role in non-shivering thermogenesis through uncoupled
reactions, where ATP hydrolysis takes place without active Ca2+ translocation.
Capsaicin (CPS) is a naturally occurring vanilloid, the consumption
of which is linked with increased metabolic rate and core body
temperature…To
the best of our knowledge CPS is the first natural drug that augments
uncoupled SERCA, presumably resulting in thermogenesis…”
Capsaicin Stimulates Uncoupled ATP
Hydrolysis by the Sarcoplasmic Reticulum Calcium Pump
Yasser A. Mahmmoud (2008)
The Journal of Biological Chemistry, 283
http://www.jbc.org/content/283/31/21418.abstract
--------------------
Synephrine
Synephrine is a naturally occurring
extract
found within the fruit of the Citrus aurantium, a short citrus
tree that produces small orange-like fruit.
General Uses:
Citrus aurantium is the Latin
name for a fruit called Seville orange, whose herbal name is Bitter
Orange. The juice, peel, and essential oil have all been used
medicinally.
Traditional uses include digestive problems, epilepsy, fatigue,
insomnia,
infections, respiratory problems, skin problems, and many other uses.
As a flavoring, essence of bitter orange is found in the drinks Triple
Sec and Cointreau.
Fat-Burning Benefits:
“…subjects in the
treatment group lost a significant amount of body weight (1.4 kg). They
also lost a significant amount of body fat (an average change of
2.9%)...Based
on these results, it was concluded that the combination of C aurantium
extract, caffeine, and St. John's Wort is safe and effective when
combined
with mild caloric restriction and exercise for promoting both body
weight
and fat loss in healthy overweight adults.”
Effects of Citrus aurantium extract,
caffeine, and St. John’s Wort on body fat loss, lipid levels, and
mood states in overweight healthy adults.
Colker, C. M., Kalman, D. S., Torina,
G. C., Perlis, T. and Street, C. (1999)
Curr Ther Res. 60, 145-153.
http://cat.inist.fr/?aModele=afficheN&cpsidt=1726318
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Gugulipid Extract
Gum guggul is the resin that exudes from
the guggul tree, Commiphora mukul. This small bushy tree, guarded by
thorny branches, grows in arid regions of India, Pakistan, and
Bangladesh
and produces a yellowish gum resin in ducts located throughout its bark.
A cut made in the bark allows the resin to seep out.
General Uses:
Gum guggul has been used in Ayurveda—the
traditional medical system of India—for more than, 2000 years to treat
a variety of ailments such as arthritis, other inflammations, weight
loss, and lipid disorders. Studies on the lipid-lowering activity of
gum guggul were first published in 1966. Since then, a number of animal
studies and clinical trials have verified its value in lowering blood
lipid levels.
The active compounds in gugulipid,
believed
to be responsible for the cholesterol-lowering properties, are two
non-anabolic
steroids: E- and Z-guggulsterone. These two steroids constitute about
2 percent by weight of gum guggul. Clinical studies conducted on humans
typically saw blood cholesterol and triglyceride levels fall by about
15 to 30 percent after two to three months when used by patients
burdened
with elevated blood lipid levels (hyperlipidemia).
Fat-Burning Benefits:
“The effects of the administration
of 50 mg of guggulipid or placebo capsules twice daily for 24 weeks…in
the management of 61 patients with hypercholesterolemia…Guggulipid
decreased the total cholesterol level by 11.7%, the low density
lipoprotein
cholesterol (LDL) by 12.5%, triglycerides by 12.0%, and the total
cholesterol/high
density lipoprotein (HDL) cholesterol ratio by 11.1% from the postdiet
levels, whereas the levels were unchanged in the placebo group…The
combined effect of diet and guggulipid at 36 weeks was as great as the
reported lipid-lowering effect of modern drugs…”
Hypolipidemic and antioxidant effects
of Commiphora mukul as an adjunct to dietary therapy in patients with
hypercholesterolemia.
Cardiovasc Singh RB, Niaz
MA, Ghosh
S. (1994)
Drugs Ther.(4):659-64.
http://www.ncbi.nlm.nih.gov/pubmed/7848901
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